Chronic atropine administration diminishes the contributon of vasoactive intestinal polypeptide to heart rate regulation

Title:

Chronic atropine administration diminishes the contributon of vasoactive intestinal polypeptide to heart rate regulation

Creator:

Jitka Kuncová, Faitová, Š., Capouch, J., Milan Štengl, and Jana Slavíková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8179c401-db71-429c-a1b8-d4826abab1a4
uuid:8179c401-db71-429c-a1b8-d4826abab1a4
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, polypeptidy, srdeční síně, potkan, physiology, polypeptides, atria of heart, Rattus norvegicus, vasoactive intestinal polypeptide, atropine, vagus nerve stimulation, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Vasoactive intestinal polypeptide (VIP) is implicated in the modulation of vagal effects on the heart rate. In this study, the impact of acute and chronic atropine administration on VIP levels in rat heart atria was investigated in relation to heart rate in the course of vagus nerves stimulation. Anaesthetised control and atropinised (10 mg/kg/day for 10 days) rats pretreated with metipranolol and phentolamine that were either given or not a single dose of atropine were subjected to bilateral vagus nerve stimulation (30 min: 0.7 mA, 20 Hz, 0.2 ms). VIP concentrations in the atria were determined afte reach stimulation protocol. In control rats with or without single atropine administration, the heart rate upon vagal stimulation was higher than in atropinised animals with or without single atropine dose, respectively. VIP concentrations in the control atria were significantly decreased after the stimulation; the decrease was comparable both in the absence and presence of a single dose of atropine. Compared to controls, VIP levels were significantly decreased after chronic atropine treatment and they were not further reduced by vagal stimulation and single atropine administration. Administration of VIP antagonist completely abolished the differences in the heart rate upon vagal stimulation between control and atropinised groups. In conclusion, the data indicate that chronic atropine administration affects VIP synthesis in rat heart atria and consequently it modifies the heart rate regulation., J. Kuncová, Š. Faitová, J. Capouch, M. Štengl, J. Slavíková., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:6

Harvested from:

CDK

Metadata only:

false