Effects of dexamethasone on pancreatic growth and thyroliberin (TRH) content in neonatal rat pancreas

Title:

Effects of dexamethasone on pancreatic growth and thyroliberin (TRH) content in neonatal rat pancreas

Creator:

Benický, J. and Štrbák, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:833564b9-d096-4f08-929d-34d3ef91572b
uuid:833564b9-d096-4f08-929d-34d3ef91572b

Subject:

pancreas, ontogenesis, thyrotropin-releasing hormone, and dexamethasone

Type:

article, model:article, and TEXT

Description:

Thyrotropin-releasing hormone (TRH) is also present in pancreatic B-cells and its role and regulation here remain unclear. The rat pancreas displays a peculiar ontogenetic pattern for TRH with a rapid increase after birth up to postnatal day 3 when TRH peak is reached. In the present study, dexamethasone (DXM) treatment (1 ¿/g/lOOg BW/day) resulted in an increase of pancreatic weight and retardation of the peak of pancreatic TRH concentration by two days. The TRH-degrading system (either in the 10 000 x g supernatant or in the pellet of pancreatic homogenate) was not stimulated by in vivo DXM treatment. In DXM-treated rats, plasma TSH levels were significantly decreased after postnatal day 1. Plasma glucose concentration was increased on day 1 (i.e. 24 h after the first DXM injection) and decreased to the control level on postnatal day 3. Pancreatic insulin levels were decreased on postnatal day 3 compared to the controls. These results indicate that DXM affects TRH in the neonatal rat pancreas; this effect is probably not mediated through modulation of TRH-degrading activity. The stimulation of pancreatic growth after DXM treatment might be related to the effect on the TRH system.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1995 Volume:44 | Number:3

Harvested from:

CDK

Metadata only:

false