Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?

Title:

Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?

Creator:

Šiarnik, Pavel, Jurík, Matúš, Hardoňová, Miroslava, Klobučníková, Katarína, Veverka, Jakub, Šurda, Pavol, Turčáni, Peter, and Kollár, Branislav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8465f54b-f32b-4627-8706-86b83c820654
uuid:8465f54b-f32b-4627-8706-86b83c820654
issn:0862-8408
doi:10.33549/physiolres.934507

Subject:

testosteron, vitamin D, testosterone, sleep-disordered breathing, polysomnography, excessive daytime sleepiness, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p˂0.001) and oxygen desaturation index (Beta=-0.150, p=0.043) were the only independent variables significantly associated with testosterone levels, and BMI (Beta=-0.142, p=0.016) was the only independent variable significantly associated with vitamin D. We failed to find any independent association of testosterone and vitamin D with subjectively rated EDS among habitual snorers. Our results suggest an independent association between the magnitude of nocturnal desaturation and testosterone levels., Pavel Šiarnik, Matúš Jurík, Miroslava Hardoňová, Katarína Klobučníková, Jakub Veverka, Pavol Šurda, Peter Turčáni, Branislav Kollár., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

907-917

Source:

Physiological research | 2020 Volume:69 | Number:5

Harvested from:

CDK

Metadata only:

false