Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice. 1.. Relationship to the number of myeloid progenitor cells

Title:

Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice. 1.. Relationship to the number of myeloid progenitor cells

Creator:

Fedoročko, P., Domonkošová, A., Kundrátová, T., Macková, N. O., Brezáni, P., and Fedoročková, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:87f7398f-fcb1-4fa7-ae67-e98e254cc14b
uuid:87f7398f-fcb1-4fa7-ae67-e98e254cc14b

Subject:

cadmium, haemopoiesis, gamma-radiation, and stem cells

Type:

article, model:article, and TEXT

Description:

The effects of single subcutaneous injection of cadmium chloride on haemopoiesis in normal (non- irradiated) or irradiated mice were investigated. Cadmium doses used ranged from 1-8 mg/kg body weight. Twenty-four hours after treatment with cadmium (doses from 3 to 8 mg/kg) there were no significant changes in bone marrow cellularity and the granulocyte-macrophage progenitor cell (GM- CFC) number per femur in non-irradiated female ICR mice. Similarly, during the 30-day postinjection period bone marrow cellularity and marrow GM-CFC number in mice treated with a cadmium dose of 5 mg/kg were not significantly different from the control values. Cadmium significantly reduced the lethal effects of gamma rays. In addition, increasing the doses of cadmium administered 24 h prior to sublethal irradiation increased the number of endogenous haemopoietic stem cells (endoCFU-S) in a concentration-dependent manner. Pretreatment with cadmium also decreased the radiation damage to endoCFU-S and haemopoietic progenitor cells committed to granulocyte/macrophage development (GM-CFC). The survival of stem cells was higher and the regeneration of cellularity and GM-CFC of irradiated bone marrow was accelerated in mice pretreated with 5 mg Cd/kg body weight in comparison with saline-injected mice.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:2

Harvested from:

CDK

Metadata only:

false