Lymphatic bioavailability of diazepam and desmethyldiazepam in the rat

Title:

Lymphatic bioavailability of diazepam and desmethyldiazepam in the rat

Creator:

Lamka, J. and Jindrová, O.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:888f1303-6691-43f7-a20d-c2be7f494657
uuid:888f1303-6691-43f7-a20d-c2be7f494657

Subject:

diazepam, desmethyldiazepam, and lymphatic bioavailability

Type:

article, model:article, and TEXT

Description:

The lymphatic bioavailability (FL) of diazepam (DZ) and its major metabolite desmethyldiazepam (DDZ) was studied. DZ was administered in intravenous and intraduodenal boluses, and in intravenous infusion in three groups of rats with different total lipid (TL) content in the central lymph. The effect of a) different lipophilicity of DZ and DDZ, b) lymphatic TL content, and c) route of DZ administration on Fl was determined. It was found that a) FL values of DZ exceeded the Fl values of DDZ and b) Fl values of DZ increased with increasing TL content in the lymph (an opposite relation was found in DDZ), and c) the highest Fl value of DZ + DDZ sum after intravenous

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:1

Harvested from:

CDK

Metadata only:

false