The influence of angiotensin II on sex-dependent proliferation of aortic VSMC isolated from SHR

Title:

The influence of angiotensin II on sex-dependent proliferation of aortic VSMC isolated from SHR

Creator:

Loukotová, J., Bačáková, L., Zicha, J., and Kuneš, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:89b7d021-233d-4e27-8a04-7b4e1a74c992
uuid:89b7d021-233d-4e27-8a04-7b4e1a74c992

Subject:

spontaneously hypertensive rat, gender, tissue culture, aortic smooth muscle cells, and angiotensin II

Type:

article, model:article, and TEXT

Description:

The growth response to angiotensin II (Ang II) was studied using cultured vascular smooth muscle cells (VSMC) isolated from the aortae of male and female spontaneously hypertensive rats (SHR). Systolic and mean arterial blood pressure of 10-week-old males was significantly higher when compared to age-matched females. The specific growth rate of male VSMC was significantly higher on the third and sixth day after synchronisation. Angiotensin II in concentration 10~7 M stimulated the specific growth rate only in male VSMC during the exponential phase of growth. Moreover, doubling time was 3 hours shorter in male VSMC in comparison with the females. Our results suggest that both the increased specific growth rate and augmented growth-response of male VSMC to Ang II may explain the higher sensitivity of males to hypertensive stimuli.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:6

Harvested from:

CDK

Metadata only:

false