Mechanisms of chronic heart failure development in end-stage renal disease patients on chronic hemodialysis

Title:

Mechanisms of chronic heart failure development in end-stage renal disease patients on chronic hemodialysis

Creator:

Jan Malík, Vladimír Tuka, Magdaléna Mokrejšová, Robert Holaj, and Vladimír Tesař

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:89e9681c-98d2-438e-acb9-bbcd3d99cd5a
uuid:89e9681c-98d2-438e-acb9-bbcd3d99cd5a

Subject:

Patologie. Klinická medicína, fyziologie, srdeční selhání, hemodialýza, human physiology, heart failure, hemodialysis, volume overload, pressure overload, 14, and 616

Type:

article, články, model:article, and TEXT

Description:

More than 50 % of end-stage renal disease (ESRD) patients treated by chronic hemodialysis die from cardiovascular diseases, including congestive heart failure (CHF). The incidence of CHF is rising in both general and ESRD population. However, the mechanisms, which lead to the development of CHF in dialyzed patients, differ considerably. First, there are several factors leading to increase of the left ventricular afterload: volume overload between dialyses, hypertension, increased arterial stiffness, anemia, vascular access flow (arteriovenous fistula) and sympathetic activation. Second, hypertension, left ventricular hypertrophy, anemia and frequently present coronary artery disease worsen myocardial oxygenation. The combination of these factors explains the high incidence of CHF in dialyzed patients and their roles are reviewed in this article., J. Malík ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:5

Harvested from:

CDK

Metadata only:

false