Ovarian reserve assessed by the anti-Mullerian hormone and reproductive health parameters in women with Crohn´s disease, a case-control study

Title:

Ovarian reserve assessed by the anti-Mullerian hormone and reproductive health parameters in women with Crohn´s disease, a case-control study

Creator:

Koller, Tomáš, Kollerová, Jana, Hlavatý, Tibor, Kadlečková, Barbora, and Payer, Juraj

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8a5f0c68-b806-4cd4-9733-16a40f224627
uuid:8a5f0c68-b806-4cd4-9733-16a40f224627
issn:0862-8408
doi:10.33549/physiolres.934776

Subject:

fyziologie člověka, lékařství, human physiology, medicine, Crohn’s disease, Ovarian reserve, Follicle depletion, AntiMullerian hormone, Reproductive health, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

According to several studies, women with Crohn's disease (CD) had reduced fertility, which is mostly due to voluntary decisions and reduced ovarian reserve. In our study, we aimed to compare reproductive health parameters (RHP), previous pregnancy complications and outcomes, and ovarian reserve (OR) assessed by the anti-Mullerian hormone (AMH) in CD patients with healthy controls. In CD patients, we also compared OR according to disease phenotypes. Consecutive pre-menopausal women with CD from two IBD centers were included. The control group consisted of age and BMI-matched healthy controls. We used a questionnaire that included RHP, CD phenotype, and CD activity. Serum AMH was assessed by the Elecsys AMH plus essay. We enrolled 50 patients and 56 controls with a median age of 31 years. All CD patients were in clinical remission. We observed no difference in RHP or AMH (median 2.6 vs. 2.1 ug/l, p = 0.98), or the proportion of low OR (AMH<1,77, 38 vs. 41.1 %, p=0.84). The slope of age-related decrease did not differ between the groups. The subgroup of CD patients after surgery and those older than 30 years with CD for >5years had a steeper decrease in AMH (slope -0.12 vs. -0.29, p = 0.04 and - 0.31 vs. -0.2, p = 0.029). In a multivariate analysis, age was the single independent predictor of low OR (OR=1.25). In women with Crohn’s disease, once the disease activity is under control, the reproductive health and ovarian reserve do not substantially differ from healthy controls., Tomáš Koller, Jana Kollerová, Tibor Hlavatý, Barbora Kadlečková, Juraj Payer., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S69-S78

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false