The metabolism of 5-methylcytosine residues in DNA

Title:

The metabolism of 5-methylcytosine residues in DNA

Creator:

Murín, R., Abdalla, M., Murínová, N., Jozef Hatok, and Dušan Dobrota

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8a789431-508f-465e-bced-9c5338506872
uuid:8a789431-508f-465e-bced-9c5338506872
issn:0862-8408

Subject:

epigenetika, epigenetics, DNA methylation, DNA demethylation, 5-methylcytosine, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The fundamental biochemical processes of 5-methylcytosine (5-mC) synthesis, maintenance, conversion and removal determine the time and spatial pattern of DNA methylation. This has a strong effect on a plethora of physiological aspects of cellular metabolism. While the presence of 5-mC within the promoter region can silence gene expression, its derivative - 5-hydroxymethylcytosine exerts an opposite effect. Dysregulations in the metabolism of 5-mC lead to an altered DNA methylation pattern which is linked with a disrupted epigenome, and are considered to play a significant part in the etiology of several human diseases. A summary of recent knowledge about the molecular processes participating in DNA methylation pattern shaping is provided here., R. Murín, M. Abdalla, N. Murínová, J. Hatok, D. Dobrota., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false