High cysteine diet reduces insulin resistance in SHR-CRP rats

Title:

High cysteine diet reduces insulin resistance in SHR-CRP rats

Creator:

Krijt, Jakub, Sokolová, Jitka, Šilhavý, Jan, Mlejnek, Petr, Kubovčiak, Jan, Liška, František, Malínská, Hana, Hüttl, Martina, Marková, Irena, Křížková, Michaela, Stipanuk, Martha H., Křížek, Tomáš, Ditroi, Tamas, Nagy, Peter, Kožich, Viktor, and Pravenec, Michal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8adae948-9616-483d-b60b-e582af88897d
uuid:8adae948-9616-483d-b60b-e582af88897d
issn:1802-9973
doi:10.33549/physiolres.934736

Subject:

inzulinová rezistence, insulin resistance, SHR-CRP rats, metabolic syndrome, taurine, cysteine, cysteine dioxygenase, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Increased plasma total cysteine (tCys) has been associated with obesity and metabolic syndrome in human and some animal studies but the underlying mechanisms remain unclear. In this study, we aimed at evaluating the effects of high cysteine diet administered to SHR-CRP transgenic rats, a model of metabolic syndrome and inflammation. SHR-CRP rats were fed either standard (3.2 g cystine/kg diet) or high cysteine diet (HCD, enriched with additional 4 g L-cysteine/kg diet). After 4 weeks, urine, plasma and tissue samples were collected and parameters of metabolic syndrome, sulfur metabolites and hepatic gene expression were evaluated. Rats on HCD exhibited similar body weights and weights of fat depots, reduced levels of serum insulin, and reduced oxidative stress in the liver. The HCD did not change concentrations of tCys in tissues and body fluids while taurine in tissues and body fluids, and urinary sulfate were significantly increased. In contrast, betaine levels were significantly reduced possibly compensating for taurine elevation. In summary, increased Cys intake did not induce obesity while it ameliorated insulin resistance in the SHR-CRP rats, possibly due to beneficial effects of accumulating taurine., Jakub Krijt, Jitka Sokolová, Jan Šilhavý, Petr Mlejnek, Jan Kubovčiak, František Liška, Hana Malínská, Martina Hüttl, Irena Marková, Michaela Křížková, Martha H. Stipanuk, Tomáš Křížek, Tamas Ditroi, Peter Nagy, Viktor Kožich, Michal Pravenec., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

687-700

Source:

Physiological research | 2021 Volume:70 | Number:5

Harvested from:

CDK

Metadata only:

false