Comparative efficacy of three brands of gum acacia on adenineInduced chronic renal failure in rats

Title:

Comparative efficacy of three brands of gum acacia on adenineInduced chronic renal failure in rats

Creator:

Ali, B. H., Beegam, S., Al-Lawati, I., Waly, M. I., Al Za´Abi, M., and Nemmar, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8b85fc88-6a35-48ae-a311-1e164c93f47e
uuid:8b85fc88-6a35-48ae-a311-1e164c93f47e

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, adenine, animal model, chronic kidney disease, gum acacia, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Gum acacia (GA) is used in pharmaceutical, cosmetic and food industries as an emulsifier and stabilizer, and in some countries in the traditional treatment of patients with chronic kidney disease (CKD). We have previously found that GA ameliorates adenine -induced chronic renal failure (CRF) in rats. Different brands of GA are commercially available, but their comparative efficacy against adenine-induced CKD is unknown. Here, we explored the effects of three different brands of GA (Sudanese GA, SupergumTM and GA from BDH) on some physiological, biochemical, and histological effects of adenine-induced CRF in rats. Adenine (0.75 %, w/w in feed, four weeks) reduced body weight, and increased urine output. It also induced significant increases in blood pressure, and in creatinine, urea, several inflammatory cytokines in plasma, and indices of oxidative stress, and caused histological damage in kidneys. Treatment of rats concomitantly with any of the three GA brands, significantly, and to a broadly similar extent, mitigated all the signs of CRF. The results suggested equivalent efficacy of these brands in antagonizing the CRF in this animal model. However, to enable standardization of different brands between laboratories, the use of the chemically well-characterized GA preparation (such as SupergumTM) is recommended., B. H. Ali, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:1

Harvested from:

CDK

Metadata only:

false