Positive effects of different drug forms of silybin in the treatment of metabolic syndrome

Title:

Positive effects of different drug forms of silybin in the treatment of metabolic syndrome

Creator:

Poruba, M., Zuzana Matušková, Ludmila Kazdová, Olena Oliyarnyk, Hana Malínská, Igor Tozzi di Angelo, and Rostislav Večeřa

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8beb53f4-a0b1-424b-a1c2-05eea7c1641c
uuid:8beb53f4-a0b1-424b-a1c2-05eea7c1641c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hyperglykémie, hyperlipidémie, hyperglycemia, hyperlipidemia, HHTg rats, metabolic syndrome, silybin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Silymarin and silybin are widely used for their hepatoprotective properties. Our previous studies confirm positive effect of silymarin on lipoprotein profile and lipid homeostasis. Advanced drug forms may improve the bioavailability of these compounds. In this study, we investigate the effects of silybin in different drug forms (standardized silybin, micronized silybin, and silybin in form of phytosomes) on dyslipidemia and glucose metabolism in hereditary hypertriglyceridemic (HHTg) rats. Male HHTg rats were divided into four groups of seven animals and were fed by experimental diets. Silybin significantly decreased serum level of triglycerides in groups of rats fed by standardized silybin and silybin in form of phytosomes compared to control group. Results show that silybin did not affect the total cholesterol level, but significantly increased the levels of HDL cholesterol in all groups of animals. Silybin in a standardized form had the highest hypotriglyceridemic effect. On the other hand, the micronized form has caused the highest increase of protective HDL and most significantly decreased glucose and insulin levels. Our results suggest that silybin is probably responsible for some positive properties of silymarin. Subsequent dose-dependent studies of silybin action may reveal the intensity of its positive effects on lipid and glucose parameters., M. Poruba, Z. Matušková, L. Kazdová, O. Oliyarnyk, H. Malínská, I. Tozzi di Angelo, R. Večeřa., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false