Orally administered whey proteins have comparable effect on C-peptide secretion in healthy subjects as standard C-peptide stimulation tests

Title:

Orally administered whey proteins have comparable effect on C-peptide secretion in healthy subjects as standard C-peptide stimulation tests

Creator:

Wildová, E., Pavel Dlouhý, Pavel Kraml, Jolana Rambousková, Šmejkalová, V., Jana Potočková, and Michal Anděl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8c6a5532-b265-4982-afa4-27d5c93fa29b
uuid:8c6a5532-b265-4982-afa4-27d5c93fa29b

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, whey proteins, pancreatic beta cell capacity tests, C-peptide, blood glucose, healthy, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Our study compared total C-peptide secretion after administration of whey proteins and whey proteins in combination with glucose with results of classical tests assessing beta cell function in the pancreas of healthy individuals. Eight young, healthy (7 males, 1 female; aged 20-26 years), nonobese (BMI: 17-25.9 kg/m2 ) participants with normal glucose tolerance underwent six C-peptide secretion tests. Three secretion tests measured C-peptide response to orally administered substances: whey proteins only (OWT), whey proteins with glucose (OWGT) and glucose only (OGTT); while three secretion tests measured C-peptide response to intravenously administered substances: arginine (AST), glucagon (GST) and glucose (IVGTT). OWT stimulated a greater (93 %, p<0.05) C-peptide response than AST and a 64 % smaller response (p<0.05) than OGTT. OWT also showed lower variability (p<0.05) in C-peptide responses compared to OWGT and OGTT. The greatest total C-peptide response was induced by OWGT (36 % higher than glucose). OWT consistently increased C-peptide concentrations with lower individual variability, while insignificantly increasing glucose levels. Results of this study suggest that both dietology and beta-cells capacity testing could take advantage of the unique property of whey proteins to induce C-peptide secretion., E. Wildová, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:2

Harvested from:

CDK

Metadata only:

false