Ultra-small gold nanoparticles with mild immunomodulatory activity as a potential tool for bio-applications

Title:

Ultra-small gold nanoparticles with mild immunomodulatory activity as a potential tool for bio-applications

Creator:

Bělinová, T., Javorová, P., Nguyenová, H. Y., Řezníčková, A., Humlová, Z., and Hubálek Kalbáčová, Marie

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8ef93917-6a6d-44cf-84c7-4ab147621123
uuid:8ef93917-6a6d-44cf-84c7-4ab147621123

Subject:

gold nanoparticles, immune cells, immunomodulation, and nanoparticle-cell interaction

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Recently, more and more efforts are directed towards developing new imaging and drug-delivery options based on various nanoparticles, exploiting their unique properties. Here, ultra-small gold nanoparticles functionalized with widely used polyethylene glycol and its amine-terminated form were tested in respect of their potential interactions with human immune cells (cell line and primary cells). The results showed that differently terminated ultrasmall gold nanoparticles represent an interesting theranostic platform as they are harmless to immune cells (not inducing cytotoxicity and severe immune response) and on the other hand, they can serve as imaging and/or drug delivery agents using e.g. monocytes/ macrophages as “Trojan horses” to deliver these nanoparticles across the blood-brain barrier and diagnose or treat pathologies of the central nervous system.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

142-152

Source:

Folia biologica | 2022 Volume:68 | Number:4

Harvested from:

CDK

Metadata only:

false