Hematological findings in non-treated and γ-irradiated mice deficient for MIC-1/GDF15

Title:

Hematological findings in non-treated and γ-irradiated mice deficient for MIC-1/GDF15

Creator:

Michal Hofer, Zuzana Hoferová, Remšík, J., Nováková, M., Procházková, J., Fedr, R., Kohoutek, J., Ladislav Dušek, Aleš Hampl, and Karel Souček

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8f0a6f45-257e-4af7-9812-326d5d907871
uuid:8f0a6f45-257e-4af7-9812-326d5d907871
issn:0862-8408

Subject:

krvetvorba, ionizující záření, hematopoiesis, ionizing radiation, GDF15 knockout mice, stress-induced cytokine, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Several members of the TGF-ß family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-ß family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and γ-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage., M. Hofer, Z. Hoferová, J. Remšík, M. Nováková, J. Procházková, R. Fedr, J. Kohoutek, L. Dušek, A. Hampl, K. Souček., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:4

Harvested from:

CDK

Metadata only:

false