The effect of indapamide on development of myocardial hypertrophy and fibrosis in L-NAME-induced hypertension in rat

Title:

The effect of indapamide on development of myocardial hypertrophy and fibrosis in L-NAME-induced hypertension in rat

Creator:

Ludmila Hlaváčková, Vranková, S., Pavol Janega, Oľga Pecháňová, and Pavel Babál

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:91369f59-2ae5-418f-9fb5-3e74add2eac6
uuid:91369f59-2ae5-418f-9fb5-3e74add2eac6

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, captopril, indapamide, LV hypertrophy, myocardial fibrosis, red wine polyphenols, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of this study was to an alyze the effect of indapamide and its combination with ACE inhi bitor (captopril) and antioxidant (ProvinolsTM) on both myocardial hypert rophy and fibrosis. Wistar rats were treated with L-NAME (40 mg/kg/day, L); L-NAME plus indapamide (1 mg/kg/day), or captopril (10 mg/kg/day), or ProvinolsTM (40 mg/kg/day), or combination of indapamide with captopril, and indapamide with Provinols TM for 7 weeks. Blood pressure (BP), LV hypertrophy an d fibrosis were determined. The content of collagens type I and III was evaluated morphometrically after picrosirius red staining. L-NAME treatment led to increased BP, LV hypertroph y, total fibrosis and relative content of collagens without th e change in collagen type I/III ratio. Indapamide and captopri l decreased BP, LV hypertrophy and the collagen ratio without affecting total fibrosis, while ProvinolsTM reduced BP, the collagen ratio and fibrosis without affecting LV hypertrophy. The combinations decreased all the parameters. Decrease of LV hypertrophy was achieved by drugs with the best reducing effect on BP, fibrosis reduction was reached by the antioxidant treatment with only partial effect on BP. Thus, the combination of an tihypertensive and antioxidant treatment may represent a powerful tool in preventing myocardial remodeling induced by hypertension., L. Hlavačková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:6

Harvested from:

CDK

Metadata only:

false