Molecular basis of TRPA1 regulation in nociceptive neurons: a review

Title:

Molecular basis of TRPA1 regulation in nociceptive neurons: a review

Creator:

Kádková, A., Synytsya, V., Krusek, J., Zímová, L., and Vlachová, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:91ddec35-f601-4658-8e61-54bfe0e9077e
uuid:91ddec35-f601-4658-8e61-54bfe0e9077e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, transient receptor potential ankyrin 1, bradykinin, structure - function, nociception, post-translational modifications, signaling pathways, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Transient receptor potential A1 (TRPA1) is an excitatory ion channel that functions as a cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants an d endogenous products of inflammation and oxidative stress. Topical application of TRPA1 agonists produces an acute nociceptive response through peripheral release of neuropeptides, purines and other transmitters from activated sensory nerve endings. This, in turn, further regulates TRPA1 activity downstream of G-protein and phospholipase C -coupled signaling cascades. Despite the important physiological relevance of such regulation leading to nociceptor sensitization and consequent pain hypersensitivity, th e specific domains through which TRPA1 undergoes post -translational modifications that affect its activation properties are yet to be determined at a molecular level. This review aims at providing an account of our current knowledge on molecular basis of r egulation by neuronal inflammatory signaling pathways that converge on the TRPA1 channel protein and through modification of its specific residues influence the extent to which this channel may contribute to pain., A. Kádková, V. Synytsya, J. Krusek, L. Zímová, V. Vlachová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:3

Harvested from:

CDK

Metadata only:

false