Intracerebroventricular endothelin receptor-A blockade in rats decreases phase-ii ventricular tachyarrhythmias during acute myocardial infarction

Title:

Intracerebroventricular endothelin receptor-A blockade in rats decreases phase-ii ventricular tachyarrhythmias during acute myocardial infarction

Creator:

Lekkas, P. , Georgiou, E. S. , Kontonika, M., Mouxtouri, E.-T., Mourouzis, I. , Pantos, K., and Kolettis, T. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:923ab90d-bfa8-4e99-8b01-f71975496c89
uuid:923ab90d-bfa8-4e99-8b01-f71975496c89
doi:10.33549/physiolres.934135

Subject:

myocardial infarction, brain, endothelin, A-receptor, and ventricular tachyarrhythmias

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were injected intracerebroventricularly. After 10 min, the left coronary artery was ligated, followed by implantation of telemetry transmitters. Electrocardiography and voluntary activity (as a surrogate of acute left ventricular failure) were continuously monitored for 24 h. Infarct-size was similar in the two groups. There were fewer episodes of ventricular tachyarrhythmias of shorter average duration in treated rats, leading to markedly shorter total duration (12.3±8.9 s), when compared to controls (546.2±130.3 s). Voluntary activity increased in treated rats during the last hours of recording, but bradyarrhythmic episodes were comparable between the two groups. Endothelin receptor-A blockade in the brain of rats decreases the incidence of ventricular tachyarrhythmias post-ligation, without affecting bradyarrhythmic episodes. These findings call for further research on the pathophysiologic role of endothelin during acute myocardial infarction.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

867-871

Source:

Physiological research | 2019 Volume:68 | Number:5

Harvested from:

CDK

Metadata only:

false