Different degrees of lipid peroxidation in the CNS of young and adult rats exposed to short-term hypobaric hypoxia

Title:

Different degrees of lipid peroxidation in the CNS of young and adult rats exposed to short-term hypobaric hypoxia

Creator:

Koudelová, J. and Mourek, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:92ee2b02-ed1b-4688-9540-0c205a6cc142
uuid:92ee2b02-ed1b-4688-9540-0c205a6cc142

Subject:

hypobaric hypoxia, lipid peroxidation, CNS development, and rat

Type:

article, model:article, and TEXT

Description:

The authors studied the effect of short-term (20 min) hypobaric hypoxia at simulated altitudes of 7000 and 9000 m on the peroxidation of lipids in the cerebral cortex, subcortical formations, medulla oblongata and cerebellum of the laboratory rat. In 5- and 21-day-old rats, increased lipoperoxidation was recorded in all the studied regions of the brain. Differences were observed in sensitivity to the degree of hypoxia. In 5-day-old rats the response to both exposures was the same, but in 21-day-old animals exposure at 7000 m stimulated peroxidation in the cerebral cortex only (at 9000 m in all the parts of the CNS examined). In 35-day-old and adult rats, changes in the malondialdehyde concentration were likewise found after exposure at 9000 m, but not in every compartment (in 35-day-old rats in the cerebral cortex and subcortical formations and in adult rats in the cerebral cortex). In young rats, 30 and 60 min after exposure to hypoxia the malondialdehyde concentration was still higher than in older animals.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:3

Harvested from:

CDK

Metadata only:

false