Effect of methylprednisolone on experimental brain edema in rats – own experience reviewed

Title:

Effect of methylprednisolone on experimental brain edema in rats – own experience reviewed

Creator:

Kozler, Petr, Marešová, Dana, and Pokorný, Jaroslav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:93fb24d6-38c1-4ff7-88c2-cd3aeba9fde7
uuid:93fb24d6-38c1-4ff7-88c2-cd3aeba9fde7
doi:10.33549/physiolres.934818

Subject:

cytotoxic edema, vasogenic edema, water intoxication, blood brain barrier disruption, and methylprednisolone

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Brain edema – a frequently fatal pathological state in which brain volume increases resulting in intracranial pressure elevation – can result from almost any insult to the brain, including traumatic brain injury. For many years, the objective of experimental studies was to find a method to prevent the development of brain edema at the onset. From this perspective, the use of methylprednisolone (MP) appears promising. High molecular MP (MW>50 kDa) can be incorporated into the brain – in the conditions of the experimental model – either by osmotic bloodbrain barrier disruption (BBBd) or during the induction of cellular edema by water intoxication (WI) – a condition that increases the BBB permeability. The time window for administration of the MP should be at the earliest stages of edema. The neuroprotective effect of MP on the permeability of cytoplasmatic membranes of neuronal populations was proved. MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S289-S300

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false