Different effects of oestradiol benzoate and norethisterone on the blood flow and mineral content in rat bones

Title:

Different effects of oestradiol benzoate and norethisterone on the blood flow and mineral content in rat bones

Creator:

Kapitola, J., Schreiber, V., Andrle, J., and Kubíčková, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9460dc8b-bb92-4f78-a1c2-1c9b738f0821
uuid:9460dc8b-bb92-4f78-a1c2-1c9b738f0821

Subject:

estradiol, norethisterone, bone blood flow, and rat

Type:

article, model:article, and TEXT

Description:

In three experiments (2 on famales,l on males),we determined the blood flow in the tibia and the distal part of the femur, together with cardiac output (by meansi of 85Sr-microspheres),tibial bone density and tibial ash weight related to bone volume. We found that 1) the bone blood flow always fell significantly after oestradiol benzoate, 2) no change occurred after norethisterone in doses corresponding to those of oestradiol benzoate, but the blood flow showed a tendency to fall after doses one order higher (it decreased significantly in one case only), 3) the density of the tibia and tibial ash weight related to bone volume rose nonsignificantly after oestradiol benzoate, but fell (mostly statistically significantly) after norethisterone. The lowering of the bone mineral indexes in rat bones after norethisterone is a surprising and potentially significant finding requiring further verification.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1992 Volume:41 | Number:5

Harvested from:

CDK

Metadata only:

false