Regulation of fetoplacental vascular bed by hypoxia

Title:

Regulation of fetoplacental vascular bed by hypoxia

Creator:

Václav Hampl and Vít Jakoubek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9545c14a-c5ca-4dd3-a955-c0c3980b8a31
uuid:9545c14a-c5ca-4dd3-a955-c0c3980b8a31

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, placenta, hypoxie, iontové kanály, physiology, hypoxia, ion channels, intrauterinní růstová restrikce, vazokonstrikce, intrauterine growth restriction, vasoconstriction, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Important fetal and perinatal pathologies, especially intrauterine growth restriction (IUGR), are thought to stem from placental hypoxia-induced vasoconstriction of the fetoplacental vessels, leading to placental hypoperfusion and thus fetal undernutrition. However, the effects of hypoxia on the fetoplacental vessels have been surprisingly little studied. We review here available experimental data on acute hypoxic fetoplacental vasoconstriction (HFPV) and on chronic hypoxic elevation of fetoplacental vascular resistance. The mechanism of HFPV includes hypoxic inhibition of potassium channels in the plasma membrane of fetoplacental vascular smooth muscle and consequent membrane depolarization that activates voltage gated calcium channels. This in turn causes calcium influx and contractile apparatus activation. The mechanism of chronic hypoxic elevation of fetoplacental vascular resistance is virtually unknown except of signs of the involvement of morphological remodeling., V. Hampl, V. Jakoubek., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false