Endothelin and diabetic complications: a brain-centric view

Title:

Endothelin and diabetic complications: a brain-centric view

Creator:

Li, W., Abdul, Y., Ergul, A., and Ward, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:97bb0a23-a07f-4c53-a078-c6355dcd5d38
uuid:97bb0a23-a07f-4c53-a078-c6355dcd5d38
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Endothelin, Cognitive impairment, Cerebrovascular dysfunction, Neurovascular unit, Diabetes, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The global epidemic of diabetes is of significant concern. Diabetes associated vascular disease signifies the principal cause of morbidity and mortality in diabetic patients. It is also the most rapidly increasing risk factor for cognitive impairment, a silent disease that causes loss of creativity, productivity, and quality of life. Small vessel disease in the cerebral vasculature plays a major role in the pathogenesis of cognitive impairment in diabetes. Endothelin system, including endothelin-1 (ET-1) and the receptors (ETA and ETB), is a likely candidate that may be involved in many aspects of the diabetes cerebrovascular disease. In this review, we took a brain-centric approach and discussed the role of the ET system in cerebrovascular and cognitive dysfunction in diabetes., W. Li, Y. Abdul, R. Ward, A. Ergul., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false