2Hz-electroacupuncture attenuates heroin-seeking behaviors via adjusts CB1-Rs and CB2-Rs expression in relapse-relevant brain regions of heroin self-administration rats

Title:

2Hz-electroacupuncture attenuates heroin-seeking behaviors via adjusts CB1-Rs and CB2-Rs expression in relapse-relevant brain regions of heroin self-administration rats

Creator:

Chen, Lin, Gong, Xiao-Kang, Leng, Chang-Long, Ma, Bao-Miao, Ru, Qin, Xiong, Qi, Yue, Kai, Zhou, Mei, Tian, Xiang, Li, Chao-Ying, and Wu, Yu-Xiang

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:98d67d39-4736-4be4-abce-852faef525d6
uuid:98d67d39-4736-4be4-abce-852faef525d6
doi:10.33549/physiolres.934106

Subject:

heroin self-administration, 2Hz-electroacupuncture, heroinseeking behaviors, and CB1-Rs and CB2-Rs

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Opiate addiction has a high rate of relapse. The accumulating evidence shows that electroacupuncture (EA) may be effective for the treatment of opiate relapse. However, the change of expression of CB1-Rs and CB2-Rs involve in 2Hz EA anti-relapse pathway is still unclear. To explore the changes of expression of CB1-Rs and CB2-Rs, heroin self-administration (SA) model rats were adopted and treated using 2Hz EA. The expressions of CB1-Rs and CB2-Rs were observed using immunohistochemistry method. The results showed that, compared with the control group, active pokes in the heroin-addicted group increased, while the active pokes decreased significantly in 2Hz EA group compared with heroin-addicted group. Correspondingly, the expression of CB1-Rs in prefrontal cortex (PFC), hippocampus (Hip), nucleus accumbens (NAc) and ventral tegmental area (VTA) all increased significantly while the expression of CB2-Rs in those relapse-relevant brain regions decreased obviously in heroin-addicted group when compared with the control group. In addition, the expression of CB1-Rs obviously decreased in the 2Hz EA group while the expression of CB2-Rs in those relapserelevant brain regions increased significantly when compared with the heroin-addicted group. It indicated that 2Hz EA could attenuate the heroin-evoked seeking behaviors effectively. The anti-relapse effects of 2Hz EA might be related to the decrease of CB1-Rs and increase of CB2-Rs expression in relapse-relevant brain regions of heroin SA rats.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

835-844

Source:

Physiological research | 2019 Volume:68 | Number:5

Harvested from:

CDK

Metadata only:

false