Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of wistar rats

Title:

Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of wistar rats

Creator:

Djordjevic, J., Djordjevic, A., Adzic, M., Niciforovic, A., and Marija B. Radojčić

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9929ba7b-02de-4ecc-a799-f614b27d86d1
uuid:9929ba7b-02de-4ecc-a799-f614b27d86d1

Subject:

Fyziologie člověka a srovnávací fyziologie, stres (fyziologie), játra, glukokortikoidy, stress (physiology), liver, glucocorticoids, antioxidant enzymes, nuclear factor kappa B, glucocorticoid receptor, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Clinical reports suggest close interactions between stressors, particularly those of long duration, and liver diseases, such as hepatic inflammation, that is proposed to occur via reactive oxygen species. In the present study we have used 21-day social isolation of male Wistar rats as a model of chronic stress to investigate protein expression/activity of liver antioxidant enzymes: superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR), and protein expression of their upstream regulators: glucocorticoid receptor (GR) and nuclear factor kappa B (NFkB). We have also characterized these parameters in either naive or chronically stressed animals that were challenged by 30-min acute immobilization. We found that chronic isolation caused decrease in serum corticosterone (CORT) and blood glucose (GLU), increase in NFkB signaling, and disproportion between CuZnSOD, peroxidases (CAT, GPx) and GLR, thus promoting H2O2 accumulation and prooxidative state in liver. The overall results suggested that chronic stress exaggerated responsiveness to subsequent stressor at the level of CORT and GLU, and potentiated GLR response, but compromised the restoration of oxido-reductive balance due to irreversible alterations in MnSOD and GPx., J. Djordjevic ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:5

Harvested from:

CDK

Metadata only:

false