Reduced levels of circulating 7α-hydroxy-dehydroepiandrosterone in treated adolescent obese patients

Title:

Reduced levels of circulating 7α-hydroxy-dehydroepiandrosterone in treated adolescent obese patients

Creator:

Ludmila Máčová, Marie Bičíková, Hana Zamrazilová, Martin Hill, Hana Kazihnitková, Barbora Sedláčková, and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9afef76c-cbe4-4b4a-9025-8178f16688a4
uuid:9afef76c-cbe4-4b4a-9025-8178f16688a4

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, obesity, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD 1), obesity, body mass index (BMI), 7-hydroxy-dehydroepiandrosterone (7-OH-DHEA), 7-oxo-dehydroepiandrosterone (7-oxo-DHEA), 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Elevated levels of glucocorticoids lead to the development of obesity and metabolic syndrome. Local glucocorticoid levels are regulated through the enzyme 11 β -hydroxysteroid dehydrogenase 1 (11 β -HSD 1), an enzyme that regenerates active cortisol from inert cortis one. Increased expression of 11 β - HSD 1 in adipose tissue promotes higher body mass index (BMI), insulin resistance, hypertension, and dyslipidemia. Human 11 β - HSD 1 is also responsible for inter-conversion of 7-hydroxylate metabolites of dehydroepiandrosterone (7-OH-DHEA) to their 7-oxo-form. To better understanding the mechanism of the action, we focused on 7-OH- and 7-ox o-DHEA, and their circulating levels during the reductive treatment in adolescent obese patients. We determined plasma levels of 7 α -OH-DHEA, 7 β -OH- DHEA, and 7-oxo-DHEA in 55 adolescent patients aged 13.04- 15.67 years, BMI greater than 90 th percentile. Samples were collected before and after one month of reductive therapy. Circulating levels of 7 α -OH-DHEA decreased during the reductive therapy from 1.727 (1.614; 1.854 , transformed mean with 95 % confidence interval) to 1.530 nm ol/l (1.435; 1.637, p<0.05) in girls and from 1.704 (1.583; 1. 842) to 1.540 nmol/l (1.435; 1.659, p<0.05) in boys. With regard to the level of 7-oxo-DHEA, a significant reduction from 1. 132 (1.044; 1.231) to 0.918 nmol/l (0.844; 1.000, p<0.05) was found after the treatment, but only in boys. No significant difference in 7 β -OH-DHEA levels was observed. In conclusions, diminished levels of 7 α -OH-DHEA indicate its possible effect on activity of 11 β -HSD 1. Further studies are necessary to clarify whether competitive substrates for 11 β -HSD 1 such as 7 α -OH-DHEA could inhibit production of glucocorticoids and may be involved in metabolic processes leading to reduction of obesity., L. Máčová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:1

Harvested from:

CDK

Metadata only:

false