Body composition is associated with bone and glucose metabolism in postmenopausal women with type 2 diabetes mellitus

Title:

Body composition is associated with bone and glucose metabolism in postmenopausal women with type 2 diabetes mellitus

Creator:

Ivan Raška, Miluše Rašková, Vít Zikán, and Jan Škrha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9dee855b-a546-496f-b43a-c03f1b1d12d9
uuid:9dee855b-a546-496f-b43a-c03f1b1d12d9
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, tělesné složení, diabetes mellitus, body composition, bone mineral density, fat mass, lean mass, type 2 diabetes mellitus, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Type 2 diabetes mellitus (T2DM) is associated with increased fracture risk; the underlying mechanism remains unexplained. This study aimed to investigate the relationships between body composition and bone and glucose metabolism in postmenopausal women wit h T2DM. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) and body composition. A total of 68 postme nopausal women with T2DM and 71 controls were eligible for the study. In contrast to normal BMD in T2DM, a similar prevalence of low-trauma fractures was observed in both groups. T2DM women had significantly higher Trunk fat% and A/G ratio and significantly lower Legs LM% and Legs FM%. Legs LM% was significantly lower in fractured T2DM group and negatively correlated with glycaem ia and HbA1c (p<0.01). Serum osteocalcin was significantly lower in T2DM and inversely correlated with FM%, Trunk FM% and A/G ratio (p<0.01) and positively correlated with Legs FM% and total LM% (p<0.05). In conclusion, abdominal obesity and decrease in mu scle mass may contribute to low bone formation in T2DM women. Further research is needed to unravel underlying pathophysiological mechanisms and to determine whether maintenance of muscle mass, especially in the lower extremities and/or reduction of centra l fat mass can prevent fractures., I. Raška Jr., M. Rašková, V. Zikán, J. Škrha., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:1

Harvested from:

CDK

Metadata only:

false