Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress

Title:

Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress

Creator:

Zdeněk Drahota, Marie Milerová, Endlicher, R., Rychtrmoc, D., Zuzana Červinková, and Bohuslav Ošťádal

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9e02a032-2db1-45aa-8a21-e1642c107473
uuid:9e02a032-2db1-45aa-8a21-e1642c107473

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, MPTP, developmental and tissue specificity, cardiac mitochondria, liver mitochondria, calcium load, oxidative stress, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Opening of the mitochondrial membrane permeability transition pore (MPTP) is an important factor in the activation of apoptotic and necrotic processes in mammalian cells. In a previous paper we have shown that cardiac mitochondria from neonatal rats are more resistant to calcium load than mitochondria from adult animals. In this study we have analyzed the ontogenetic development of this parameter both in heart and in liver mitochondria. We found that the high resistance of heart mitochondria decreases from day 14 to adulthood. On the other hand, we did not observe a similar age-dependent sensitivity in liver mitochondria, particularly in the neonatal period. Some significant but relatively smaller increase could be observed only after day 30. When compared with liver mitochondria cardiac mitochondria were more resistant also to the peroxide activating effect on calcium-induced mitochondrial swelling. These data thus indicate that the MPTP of heart mitochondria is better protected against damaging effects of the calcium load and oxidative stress. We can only speculate that the lower sensitivity to calcium-induced swelling may be related to the higher ischemic tolerance of the neonatal heart., Z. Drahota, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false