Partial agonist of benzodiazepine receptors ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats

Title:

Partial agonist of benzodiazepine receptors ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats

Creator:

Hana Kubová and Pavel Mareš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9f3468af-0a35-4827-919e-6d5bea71f2da
uuid:9f3468af-0a35-4827-919e-6d5bea71f2da

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Ro 19-2088, iatrogenic withdrawal, pentylentetrazol-induced seizures, immature rats, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Repeated administration of partial agonist of benzodiazepine receptors Ro 19-8022 (a derivative of quinolizine class) does not elicit withdrawal in adult rats. Our older data demonstrated that single injection of Ro 19-2088 to immature rats induces increased sensitivity to convulsant action of pentylenetetrazol as a withdrawal phenomenon. To know if repeated administration of the partial agonist has the same effect we injected rats at postnatal days 7 to 11 with an anticonvulsant dose of Ro 19-2088 (0.5 mg/kg i.p.) and tested them 24 h, 48 h and 4 days after the last injection. Repeated administration of Ro 19-8022 resulted also in an increased sensitivity to convulsant action of pentylenetetrazol in immature rats (higher incidence and severity of seizures). This effect was significant 24 h after the last injection but only outlined 48 h after administration. No signs of hypersensitivity were seen at 4-day interval. There is a difference between immature and adult brain in an appearance of withdrawal symptom after administration of the partial agonist of benzodiazepine receptors Ro 19-2088., H. Kubová, P. Mareš., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:3

Harvested from:

CDK

Metadata only:

false