Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of KATP channels

Title:

Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of KATP channels

Creator:

Bazargan, Maryam, Faghihi, M., and Chitsaz, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9fba0804-b24b-4bf1-ba3e-aaf3fce586b1
uuid:9fba0804-b24b-4bf1-ba3e-aaf3fce586b1
issn:0862-8408

Subject:

Experimentální medicína, fyziologie, hořčík, physiology, magnesium, KATP channel, preconditioning, reperfusion, diazoxide, glibenclamide, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

There is a growing interest for the beneficial effect of magnesium (Mg) in cardiovascular disorders. A number of cardiovascular disorders including myocardial infarction, arrhythmias and congestive heart failure have been associated with low extracellular or intracellular concentrations of Mg. The efficiency of the preconditioning effect of Mg on cardiac function and infarct size in the globally ischemic-reperfused isolated rat heart was studied together with the role of ATP-sensitive potassium (KATP) channels in protection induced by Mg. Rat hearts were Langendorff perfused, subjected to 30 min of global ischemia and 90 min of reperfusion, including treatment groups which focused on different times of Mg (8 mmol/l) use. Infarct size was measured by triphenyltetrazolium chloride (TTC) method. The left ventricular function was assessed by left ventricular developed pressure (LVDP), heart rate (HR) and coronary flow (CF). The administration of Mg before ischemia had an anti-infarct effect in rat hearts and improved cardiac function. The protective effects of magnesium was abolished by the blocking of KATP channels and suggests that K-ATP channel has an important role in the heart protection effect of Mg as a preconditioning agent., M. Bazargan, M. Faghihi, M. Chitsaz., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:6

Harvested from:

CDK

Metadata only:

false