May alcohol-induced increase of HDL be considered as atheroprotective?

Title:

May alcohol-induced increase of HDL be considered as atheroprotective?

Creator:

Ivana K. Lesná, Pavel Suchánek, Petr Stávek, and Rudolf Poledne

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a02497ce-2685-46f8-b317-466b7edc5d9e
uuid:a02497ce-2685-46f8-b317-466b7edc5d9e

Subject:

Fyziologie člověka a srovnávací fyziologie, lipoproteiny, lipoproteins, reverse cholesterol transport, cholesterol efflux, alcohol consumption, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

It is well known that the consumption of moderate doses of alcohol leads to the increase of HDL-cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT). In the study with a crossover design 13 male volunteers were studied in two different regimens: i) drinking of 36 g alcohol daily and ii) drinking only non-alcoholic beverages, to test whether alcohol-induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labeled human macrophages. Alcohol consumption induced significant (p<0.05) increases of HDL cholesterol from 1.25±0.32 to 1.34±0.38 mmol/l and Apo A1 from 1.34±0.16 to 1.44±0.19 g/l. These changes were combined with a slight increase of cholesterol efflux from 13.8±2.15 to 14.9±1.85 % (p=0.059). There were significant correlations between individual changes of HDL-C and Apo A1 concentrations and individual changes of CHE (0.51 and 0.60, respectively). In conclusion, moderate alcohol consumption changes the capacity of plasma to induce CHE only at a border line significance., I. Králová Lesná ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:3

Harvested from:

CDK

Metadata only:

false