Effects of L-malate on mitochondrial oxidoreductases in liver of aged rats

Title:

Effects of L-malate on mitochondrial oxidoreductases in liver of aged rats

Creator:

Wu, J.-L., Wu, Q.-P., Peng, Y.-P., and Zhang, J.-M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a0ac1c6a-9242-43c3-8c9c-173db76a78b6
uuid:a0ac1c6a-9242-43c3-8c9c-173db76a78b6

Subject:

Fyziologie člověka a srovnávací fyziologie, stárnutí, mitochondrie, aging, mitochondrias, L-malate, electron transport chain, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Accumulation of oxidative damage has been implicated to be a major causative factor in the decline in physiological functions that occur during the aging process. The mitochondrial respiratory chain is a powerful so urce of reactive oxygen species (ROS), considered as the pathogen ic agent of many diseases and aging. L-malate, a tricarboxylic acid cycle intermediate, plays an important role in transporting NADH from cytosol to mitochondria for energy production. Previous studies in our laboratory reported L-malate as a free radical scavenger in aged rats. In the present study we focused on the effect of L-malate on the activities of electron transport chain in young and aged rats. We found that mitochondrial membrane potential (MMP) and the activities of succinate dehydrogenase, NADH-cytochrome c oxidoreductase and cytochrome c oxidase in liver of aged rats were significantly decreased when compared to young control rats. Supplementation of L-malate to aged rats for 30 days slightly increased MMP and improved the activities of NADH-dehydrogenase, NADH-cytochrome c oxidoreductase and cytochrome c oxidase in liver of aged rats when compared with aged control rats. In young rats, L-malate administration increased only the activity of NADH-dehydrogenase. Our result suggested that L-malate could improve the activities of electron transport chain enzymes in aged rats., J.-L. Wu ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:2

Harvested from:

CDK

Metadata only:

false