Adipose tissue macrophages and atherogenesis - a synergy with cholesterolaemia

Title:

Adipose tissue macrophages and atherogenesis - a synergy with cholesterolaemia

Creator:

Poledne, Rudolf and Králová Lesná, Ivana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a3340cbd-1248-4e5a-abb5-e4657017f248
uuid:a3340cbd-1248-4e5a-abb5-e4657017f248
doi:10.33549/physiolres.934745

Subject:

inflammation, adipose tissue macrophages, plasma membrane, cholesterol, and ω3 fatty acids

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Excessive LDL cholesterol concentration together with subclinical inflammation, in which macrophages play a central role, are linked pathologies. The process starts with the accumulation of macrophages in white adipose tissue and the switch of their polarization toward a pro-inflammatory phenotype. The proportion of pro-inflammatory macrophages in adipose tissue is related to the main risk predictors of cardiovascular disease. The cholesterol content of phospholipids of cell membranes seems to possess a crucial role in the regulation of membrane signal transduction and macrophage polarization. Also, different fatty acids of membrane phospholipids influence phenotypes of adipose tissue macrophages with saturated fatty acids stimulating pro-inflammatory whereas ω3 fatty acids antiinflammatory changes. The inflammatory status of white adipose tissue, therefore, reflects not only adipose tissue volume but also adipose tissue macrophages feature. The beneficial dietary change leading to an atherogenic lipoprotein decrease may therefore synergically reduce adipose tissue driven inflammation.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S535-S549

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 4

Harvested from:

CDK

Metadata only:

false