Role of 5-HT2 receptors family in the allergy-induced increased aorta contractile responses to 5-HT

Title:

Role of 5-HT2 receptors family in the allergy-induced increased aorta contractile responses to 5-HT

Creator:

Campos-Bedolla, Patricia, Torrejón-González, Emmanuel Gilberto, Mendoza-Mejía, Dinora, Vargas, Mario H., Segura-Medina, Patricia, Carbajal, Verónica, Rodríguez-Márquez, Aniller, and Martínez-Silva, Ana Valeria

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a925733f-ad42-4c85-a5e4-7eca2ff8eb56
uuid:a925733f-ad42-4c85-a5e4-7eca2ff8eb56
doi:10.33549/physiolres.934968

Subject:

5-HT2 receptors, asthma model, thoracic aorta, serotonin, and vascular smooth muscle

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Asthma poses an increased risk for cardiovascular disorders, suggesting that allergy, which is an underlying process in asthma, causes atypical functioning of organs other than lungs. In a previous study in a guinea pig asthma model, we concluded that allergic sensitization increased aorta contractile responses to 5-HT. To further characterize these responses, here we explored the role of the 5-HT2 receptors family. We found that TCB-2 (5-HT2A agonist) and WAY161503 (5-HT2C agonist) induced aorta contractions resembling those elicited by 5-HT but less intense (~43 % and ~25 %, respectively). In these experiments, aortas from sensitized guinea pigs showed increased contractions to TCB-2, but not to WAY161503. In turn, MDL 100907 (5-HT2A antagonist) and RS-102221 (5-HT2C antagonist) caused a notably and a mild reduction of the 5-HT-induced contractions, respectively, with no differences seen between sensitized and non-sensitized tissues. BW723C86 (5-HT2B agonist) did not induce contractile responses and RS-127445 (5-HT2B antagonist) did not modify the contractile responses to 5-HT. In nonsensitized aortas, the pattern of protein expression of receptors was 5HT2B>5-HT2A=5-HT2C, which did not change in sensitized animals. In conclusion, we found that allergic sensitization increased the aorta contractile responses to 5-HT, partly mediated by enhanced responses of 5-HT2A receptors, which was unrelated to changes in the expression of these receptors.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

111-116

Source:

Physiological research | 2023 Volume:72 | Number:1

Harvested from:

CDK

Metadata only:

false