Influence of vitamin C status on ethanol metabolism in guinea-pigs

Title:

Influence of vitamin C status on ethanol metabolism in guinea-pigs

Creator:

Ginter, E., Zloch, Z., and Ondreička, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:aa219e70-efaf-48f5-8c85-8cc410366d65
uuid:aa219e70-efaf-48f5-8c85-8cc410366d65

Subject:

vitamin C, ethanol, acetaldehyde, and metabolism

Type:

article, model:article, and TEXT

Description:

Guinea-pigs were maintained for 5 weeks on a diet containing three different concentrations of vitamin C: a) traces (none added), b) medium (0.05 % w/w) and high (0.5 % w/w). Twenty-four hours before killing the animals received one i.p. dose of 3 g ethanol per kg body weight (a model of short-term acute intoxication). In a parallel experiment which lasted 5 weeks, the animals were treated every week with two i.p. doses of 1 g ethanol per kg body weight followed bv the final acute intoxication (3 g ethanol/kg) (a model of long-term chronic alcoholization). In both experiments, the guinea-pigs with the highest tissue concentration of vitamin C proved to have significantly decreased residual levels of ethanol and acetaldehyde in the liver and the brain, a decreased activity of alanine- and aspartate aminoacyl transferases in the serum and decreased contents of triacylglycerols and cholesterol in the serum and liver in comparison with the vitamin C-unsupplemented group. The regression curve expressing vitamin C levels versus residual ethanol and acetaldehyde concentrations in the liver confirmed the highly significant negative correlation between them. Administration of the guinea-pigs with large amounts of vitamin C appears to accelerate ethanol and acetaldehyde metabolism and reduce some of their adverse health effects.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:2

Harvested from:

CDK

Metadata only:

false