Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression

Title:

Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression

Creator:

Ramkumar, N., Stuart, D., Kohan, D. E., and Abraham, N.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:ae1a6256-ccb6-4f5e-a8c0-b84fcc269109
uuid:ae1a6256-ccb6-4f5e-a8c0-b84fcc269109
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Endothelin, Prorenin, Collecting duct, Knockout, Receptor, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption. It is unknown if the CD ET and renin/PRR systems interact, hence we examined the effects of deleting CD renin or nephron PRR on CD ET system components. PRR knockout (KO) mice were polyuric and had markedly increased urinary ET-1 and inner medullary CD (IMCD) ET-1 mRNA. PRR KO mice had greatly increased IMCD ETA receptor mRNA and protein, while ETB mRNA and protein were decreased. Water loaded wild-type mice with similar polyuria as PRR KO mice had modestly increased urinary ET-1 excretion and inner medullary ET-1 mRNA, while inner medullary ETA and ETB mRNA or protein expression were unaffected. In contrast to PRR KO, CD prorenin/renin KO did not alter ET system components. Taken together, these results suggest that the nephron PRR is involved in regulating CD ET system expression, but this effect may be independent of CD-derived renin., N. Ramkumar, D. Stuart, N. Abraham, D. E. Kohan., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false