Hormone metabolism in the pulmonary circulation

Title:

Hormone metabolism in the pulmonary circulation

Creator:

Aliberti, G., Pulignano, I., Proietta, M., Miraldi, F., Cigognetti, L., Tritapepe, L., Di Giovanni, C., Arzilla, R., Vecci, E., and Toscano, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:af625e80-79c0-4e71-98ed-313c0d8edf8e
uuid:af625e80-79c0-4e71-98ed-313c0d8edf8e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hormony štítné žlázy, plíce, inzulín, glukagon, thyroid hormones, lungs, insulin, glucagon, peptide hormones, endothelial cleavage, peptide degradation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We measured hormonal levels in blood samples from pulmonary and radial arteries in 117 patients undergoing aorto-coronary by-pass surgery with the aim of investigating the role of the pulmonary vessel endothelium in hormone metabolism. Insulin and glucagon concentrations were significantly higher in pulmonary artery blood with respect to radial artery blood (73±65 vs. 65±47 pmol/l, p<0.005, and 80+49 vs. 73+51 ng/l, p<0.01, respectively), while no difference was found for growth hormone, prolactin, C peptide, insulin-like growth factor I, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, parathyroid hormone, thyroglobulin, triiodothyronine, thyroxine, free triiodothyronine, and free thyroxine. Moreover, prolactin concentrations were more than twice the normal levels, this being an effect of propafol and the opiate fentanyl used for the general anesthesia. Assuming that the arteriovenous differences observed are a marker of peptide hormone degradation, our study has demonstrated that with similar kinetics insulin and glucagon secreted into portal circulation and escaping from hepatic extraction undergo further homeostatic removal of about 9-10 % in the pulmonary circulation before entering the general circulation., G. Aliberti, I. Pulignano, M. Proietta, F. Miraldi, L. Cigognetti, L. Tritapepe, C. Di Giovanni, R. Arzilla, E. Vecci, M. Toscano., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:3

Harvested from:

CDK

Metadata only:

false