Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study

Title:

Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance: the DIOGENES study

Creator:

Marie Kunešová, Petr Hlavatý, Eva Tvrzická, Barbora Staňková, Kalousková, P., Viguerie, N., Larsen, T. M., Van Baak, M. A., Jebb, S. A., Martinez, J. A., Pfeiffer, A. F. H., Kafatos, A., Handjieva-Darlenska, T., Hill, M., Langin, D., Žák, A., Astrup, A., and Wim H. M. Saris

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b10440f8-85dc-4861-8cb9-af9ab4d616a3
uuid:b10440f8-85dc-4861-8cb9-af9ab4d616a3

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, diet, palmitoleic acid, fatty acids, adipose tissue, obesity management, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. Objective was to assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8 % weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors., M. Kunešová, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:6

Harvested from:

CDK

Metadata only:

false