Up-regulation of CD163 expression in subpopulations of blood monocytes after kidney allograft transplantation

Title:

Up-regulation of CD163 expression in subpopulations of blood monocytes after kidney allograft transplantation

Creator:

Čurnová, Lenka, Mezerová, Kristýna, Švachová, Veronika, Fialová, Martina, Novotný, Marek, Čečrdlová, Eva, Viklický, Ondřej, and Stříž, Ilja

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b12cd018-6b6d-4e64-aeaa-803521734c16
uuid:b12cd018-6b6d-4e64-aeaa-803521734c16
issn:0862-8408
doi:10.33549/physiolres.934531

Subject:

transplantace ledvin, kidney transplantation, CD163, blood monocytes, subpopulations, acute rejection, CD14+CD16+, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

M2 macrophages expressing CD163 are known to suppress immune responses but have been also found in biopsies of patients with chronic kidney allograft injury associated with interstitial fibrosis. The aim of our study was to evaluate the expression of CD163 in blood monocytes, precursors of tissue macrophages, in kidney allograft recipients with uncomplicated outcome (n=94) compared with those developing acute rejection (n=44). Blood samples were collected before the transplantation and at 1 week, 1 month and 1 year. The expression of CD163 increased during the first week after the transplantation not only in classical (CD14+CD16- ) but also in intermediate (CD14+CD16+) and nonclassical (CD14lowCD16+) monocytes in all patients regardless of their rejection status. In patients developing acute rejection, higher pre-transplant expression of CD163 on blood monocytes was found. In vitro experiments confirmed strong induction of membrane CD163 on monocytes together with CD206 (an alternative marker of M2 macrophages) in response to IL-10. We assume from our data that dramatic upregulation of CD163 by peripheral blood monocytes may have a pathophysiological role in early phases after kidney allograft transplantation and high pre-transplant expression of CD163 on blood monocytes might be involved in events leading to acute rejection., Lenka Čurnová, Kristýna Mezerová, Veronika Švachová, Martina Fialová, Marek Novotný, Eva Čečrdlová, Ondřej Viklický, Ilja Stříž., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

885-896

Source:

Physiological research | 2020 Volume:69 | Number:5

Harvested from:

CDK

Metadata only:

false