Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress

Title:

Interaction between single nucleotide polymorphism in catalase gene and catalase activity under the conditions of oxidative stress

Creator:

Komina, A. V., Korostileva, K. A., Gyrylova, S. N., Belonogov, R. N., and Ruksha, T. G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b13a8281-742c-44cc-ad7c-82eb70691398
uuid:b13a8281-742c-44cc-ad7c-82eb70691398

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, catalase, polymorphism, free radicals, H2 O2, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species. The –262C>T polymorphism in the promoter region of catalase gene was found to be associated with altered catalase levels. In this study, peripheral blood mononuclear cells catalase activity was measured after H2 O2-induced oxidative stress. C/T and T/T genotypes were associated with the decrease of catalase levels in contrast to C/C donors who had elevated catalase activity in the presence of 0.4 and 0.7 mM H2 O2. Genotypedependent response of catalase activity to oxidative stress might be related to the predisposition of catalase mutant allele carriers to disorders mediated by oxidative stress., A. V. Komina, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:6

Harvested from:

CDK

Metadata only:

false