Effect of short- and long-term administration of Baclofen on spatial learning and memory in rats

Title:

Effect of short- and long-term administration of Baclofen on spatial learning and memory in rats

Creator:

Holajová, M and Franěk, M

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b5ace750-cbed-49cc-9a14-500c509cd99d
uuid:b5ace750-cbed-49cc-9a14-500c509cd99d
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Baclofen, Spatial learning, Memory, Short-term administration, Long-term administration, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Baclofen is the only clinically available metabotropic GABAB receptor agonist. In our experiment, we tested the hypothesis that long-term baclofen administration can impair learning and memory in rats. The experiment consisted of three parts. In the first part of the study the drug was administered simultaneously with the beginning of the behavioral tests. In the second and third part of the experiment baclofen was administered daily for 14 days and for one month before the tests. In each part of the experiment, adult rats were randomly divided into four treatment groups. Three groups were given an injection of baclofen at doses of 1 mg/kg, 5 mg/kg, 10 mg/kg, while the fourth group was injected with saline. The injections were given after each session. Spatial learning and memory were tested using the Morris water maze, involving three types of tests: Acquisition, Probe, and Re-acquisition. This work reveals that baclofen did not affect spatial learning at any of the tested doses and regardless of the length of administration. Memory was observed to be affected, but only at the highest dose of baclofen and only temporarily. This conclusion is in line with previously published clinical cases., M. Holajová, M. Franěk., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:1

Harvested from:

CDK

Metadata only:

false