Determinants of adrenal androgen hypofunction in premenopausal females with rheumatoid arthritis

Title:

Determinants of adrenal androgen hypofunction in premenopausal females with rheumatoid arthritis

Creator:

Richard Imrich, Vlcek, M., Kerlik, J., Vogeser, M., Kirchhoff, F., Adela Penesová, Radikova, Z., Lukac, J., and Jozef Rovenský

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b7cf9a11-fb90-4cc8-8c79-43ec1b1905c9
uuid:b7cf9a11-fb90-4cc8-8c79-43ec1b1905c9
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, revmatoidní artritida, kortizol, rheumatoid arthritis, cortisol, hypothalamic-pituitary-adrenal axis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of our study was to investigate adrenocortical function in the context of disease activity and inflammatory status in premenopausal RA females. Adrenal glucocorticoid and androgen responses to the 1 μg ACTH 1-24 test were investigated in 23 premenopausal RA and in 15 age- and BMI-matched healthy females. Twelve RA patients were on low-dose prednisone (<8.5 mg/day). Patients with DAS28>3.2 had lower (p<0.05) total plasma cortisol, 17-hydroxyprogesterone, dehydroepiandrosterone and androstenedione responses in the ACTH test compared to healthy controls. Patients with DAS28>3.2 had lower (p<0.05) dehydroepiandrosterone response in the ACTH test compared to patients with DAS28≤3.2. C-reactive protein (CRP), DAS28, and interleukin (IL)-6 negatively correlated with androstenedione response to ACTH 1-24. Responses of all measured adrenal steroids were lower (p<0.05) in patients on low-dose glucocorticoids compared to healthy controls. RA patients not treated with glucocorticoids had lower total cortisol response (p=0.038) but did not differ in free plasma cortisol in the ACTH test. The results indicate an association of increased disease activity with a decrease in adrenal androgen production in RA and normal cortisol bioavailability in patients not treated with glucocorticoids., R. Imrich, M. Vlcek, J. Kerlik, M. Vogeser, F. Kirchhoff, A. Penesova, Z. Radikova, J. Lukac, J. Rovensky., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:3

Harvested from:

CDK

Metadata only:

false