Proinflammatory status, genetics and atherosclerosis

Title:

Proinflammatory status, genetics and atherosclerosis

Creator:

Rudolf Poledne, Alena Lorenzová, Petr Stávek, Zdeněk Valenta, Jaroslav Hubáček, Pavel Suchánek, and Jan Piťha

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b8ef39ee-2591-4f10-8ef2-3d31062cf909
uuid:b8ef39ee-2591-4f10-8ef2-3d31062cf909

Subject:

Patologie. Klinická medicína, klinické lékařství, ateroskleróza, záněty, genetika, clinical medicine, atherosclerosis, inflammations, genetics, C-reaktivní protein, C-reactive protein, 14, and 616

Type:

article, články, model:article, and TEXT

Description:

Over the last decade, C-reactive protein concentration analyzed by the high sensitivity method (hsCRP) has been proven as a marker of premature atherosclerosis. Concentration exceeding 2 mg/l represents an increased individual risk of myocardial infarction and stroke but strict application of this borderline is complicated by relations of CRP concentrations to other risk factors of cardiovascular diseases. In a large 1 % representative sample of the Czech population, a positive relation of hsCRP to BMI, a waist circumference and triglyceride concentration was documented. Substantial sex differences were found in its relationship to age. Whereas it is continuously increasing in men, this increase appears in women only after menopause. A substantial decrease of body weight and visceral fat volume by increased physical activity is accompanied by significant decrease of hsCRP in young obese women. This decrease was not related to a change of interleukin-6 concentration, although it is supposed to regulate CRP production. CRP concentration is partly under genetic control as a higher concentration in young siblings of probands with proved coronary atherosclerosis was documented. The participation of genes related to lipoprotein metabolism (genes for apolipoprotein CI and apolipoprotein E) influence hsCRP concentrations. We hypothesized that an increased concentration of hsCRP represents a certain marker of proinflammatory status related to central obesity and triglyceride metabolism and it might be related to individual properties of monocytes in atherogenesis., R. Poledne ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false