Fatty acid composition indicates two types of metabolic syndrome independent of clinical and laboratory parameters

Title:

Fatty acid composition indicates two types of metabolic syndrome independent of clinical and laboratory parameters

Creator:

Aleš Žák, Burda, M., Marek Vecka, Zeman, M., Eva Tvrzická, and Barbora Staňková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bbf539cb-e47c-400a-b258-b8654f899628
uuid:bbf539cb-e47c-400a-b258-b8654f899628
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, mastné kyseliny, shluková analýza, fatty acids, cluster analysis, metabolic syndrome, delta desaturase activities, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Dietary composition and metabolism of fatty acids (FA) influence insulin resistance, atherogenic dyslipidemia and other components of the metabolic syndrome (MS). It is known that patients with MS exhibit a heterogeneous phenotype; however, the relationships of individual FA to MS components have not yet been consistently studied. We examined the plasma phosphatidylcholine FA composition of 166 individuals (68F/98M) with MS and of 188 (87F/101M) controls. Cluster analysis of FA divided the groups into two clusters. In cluster 1, there were 65.7 % of MS patients and 37.8 % of controls, cluster 2 contained 34.3 % of patients and 62.2 % of controls (P<0.001). Those with MS within cluster 1 (MS1) differed from individuals with MS in cluster 2 (MS2) by concentrations of glucose (P<0.05), NEFA (P<0.001), HOMA-IR (P<0.05), and levels of conjugated dienes in LDL (P<0.05). The FA composition in MS1 group differed from MS2 by higher contents of palmitoleic (+30 %), γ-linolenic (+22 %), dihomo-γ-linolenic (+9 %) acids and by a lower content of linoleic acid (–25 %) (all P<0.01). These FA patterns are supposed to be connected with the progression and/or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance)., A. Žák, M. burda, M. Vecka, M. Zeman, E. Tvrzická, B. Staňková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false