Glycotoxines, carbonyl stress and relevance to diabetes and its complications

Title:

Glycotoxines, carbonyl stress and relevance to diabetes and its complications

Creator:

Turk, Z.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bd9ac52a-cb66-4629-968d-9f6cc51e84c2
uuid:bd9ac52a-cb66-4629-968d-9f6cc51e84c2

Subject:

Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, glyoxal, carbonyl stress, methylglyoxal, 3-deoxyglucosone, advanced glycation end-product, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the pathophysiological effects of α-oxoaldehydes in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyls methylglyoxal, glyoxal and 3-deoxyglucosone, formed as glycolytic intermediates during metabolic conversion of glucose, via Maillard reaction by degradation of glycated proteins, and during lipid peroxidation process. Their role in the advanced glycation process and detrimental effects on vascular tissue are discussed., Z. Turk., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:2

Harvested from:

CDK

Metadata only:

false