Fluorescent probes for monitoring cholesterol trafficking in cells

Title:

Fluorescent probes for monitoring cholesterol trafficking in cells

Creator:

Králová, J. and Král, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bef9b9bf-f68f-4f96-95b9-c1960bd0d8a8
uuid:bef9b9bf-f68f-4f96-95b9-c1960bd0d8a8

Subject:

cholesterol, sterol, cholesterol analogues, fluorescent probes, trafficking, and cellular transport

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Cellular cholesterol plays fundamental and diverse roles in many biological processes and affects the pathology of various diseases. Comprehensive and detailed understanding of the cellular functions and characteristics of cholesterol requires visualization of its subcellular distribution, which can be achieved by fluorescence microscopy. Many attempts have been made to develop fluorescent cholesterol reporters, but so far, none of them seems to be ideal for studying all aspects of cholesterol management. To meet the requirements for the right probe remains a great challenge, and progress in this field continues. The main objective of this review is to not only present the current state of the art, but also critically evaluate the applicability of individual probes and for what purpose they can be used to obtain relevant data. Hence, the data obtained with different probes might provide complementary information to build an integrated picture about the cellular cholesterol. and Corresponding author: Jarmila Králová

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

[1]-10

Source:

Folia biologica | 2019 Volume:65 | Number:1

Harvested from:

CDK

Metadata only:

false