Regulation of the SOX3 gene expression by retinoid receptors

Title:

Regulation of the SOX3 gene expression by retinoid receptors

Creator:

Nikčević, G., Kovačević-Grujičić, N., Mojsin, M., Krstić, A., Savić, T., and Stevanović, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bf502616-a235-4938-bffd-e506f8db1c96
uuid:bf502616-a235-4938-bffd-e506f8db1c96

Subject:

Fyziologie člověka a srovnávací fyziologie, retinoidy, retinoids, SOX3, retinoic acid, retinoid receptors, embryonal carcinoma cells, neuronal differentiation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Sox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements in volved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantl y, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood., G. Nikčević ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false