Pneumocystis pneumonia during medicamentous treatment of Cushing’s syndrome – a description of two cases

Title:

Pneumocystis pneumonia during medicamentous treatment of Cushing’s syndrome – a description of two cases
Pneumocystis pneumonia during medicamentous treatment of Cushing’s syndrome – a description of two cases

Creator:

Gabalec, Filip, Zavřelová, Alžběta, Havel, Eduard, Cerman, Jaroslav, Radocha, Jakub, Svilias, Ioannis, and Čáp, Jan

Contributor:

Gabalec, Filip, Zavřelová, Alžběta, Havel, Eduard , 1962-, Cerman, Jaroslav, Radocha, Jakub , 1981-, Svilias, Ioannis, and Čáp, Jan , 1953-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12000522-c7eca40c-1b4f-4c68-b569-40b424ace41f
uuid:bmc12000522-c7eca40c-1b4f-4c68-b569-40b424ace41f
local:bmc12000522
http://www.lfhk.cuni.cz/Data/files/Casopisy/2011/2011_127.pdf
local: bmc12000522

Subject:

Cushingův syndrom--diagnóza--farmakoterapie--chirurgie, glukokortikoidy--aplikace a dávkování--škodlivé účinky, pneumocystová pneumonie--diagnóza--farmakoterapie--chemicky indukované, Pneumocystis--izolace a purifikace--patogenita--účinky léků, adrenokortikální hyperfunkce--farmakoterapie, lidé, lidé středního věku, mladý dospělý, and ženské pohlaví

Type:

model:article, article, Text, kazuistiky, and TEXT

Format:

braille, text, and regular print

Description:

Only a few cases of pneumocystis pneumonia (PCP) in Cushing’s syndrome have been published in the literature so far. In the majority of these patients, the pneumonia occurred after reduction of the hypercortisolism with medicamentous treatment. We report two cases of PCP during conservative treatment of hypercortisolism. We describe clinical, imaging and laboratory findings in two patients and review published cases of pneumocystits pneumonia in Cushing’s syndrome. A 60-year-old woman and 20-year-old man with Cushing’s syndrome due to ectopic ACTH syndrome were treated at our department. Both developed pneumocystis pneumonia early after treatment with ketoconazole and ethomidate bromide had been introduced and the levels of cortisol rapidly decreased. PCP prophylaxis in patients with high cortisolemia should be started before treatment of hypercortisolism in current practice. Gradual lowering of plasma cortisol should also reduce the risk of infection by Pneumocystis jiroveci., Filip Gabalec, Alžběta Zavřelová, Eduard Havel, Jaroslav Cerman, jr., Jakub Radocha, Ioannis Svilias, Jan Čáp, and Literatura 10

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2011 Volume:54 | Number:3

Harvested from:

CDK

Metadata only:

false

Date:

2011