Expression of matrix metalloproteinase 9 in patients with Oral Lichen planus

Title:

Expression of matrix metalloproteinase 9 in patients with Oral Lichen planus
Expression of matrix metalloproteinase 9 in patients with Oral Lichen planus

Creator:

Paulusová, Vladimíra, Laco, Jan, Dřízhal, Ivo, and Slezák, Radovan

Contributor:

Paulusová, Vladimíra, Laco, Jan , 1979-, Dřízhal, Ivo , 1939-, and Slezák, Radovan , 1958-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12017013-5910fb6b-fa55-4c22-a624-8bf520d74787
uuid:bmc12017013-5910fb6b-fa55-4c22-a624-8bf520d74787
local:bmc12017013
http://www.lfhk.cuni.cz/Data/files/Casopisy/2012/2012_23.pdf
local: bmc12017013

Subject:

fibrom--metabolismus--patologie, lidé, lichen planus orální--metabolismus--patologie, matrixová metaloproteinasa 9--metabolismus, ústní sliznice--metabolismus--patologie, and nádory úst--metabolismus--patologie

Type:

model:article, article, Text, statistics, práce podpořená grantem, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

Introduction: Oral Lichen planus (OLP) is chronic inflammatory oral mucosal disease of unknown etiology. Basement membrane damage and T‑cell migration in OLP may be mediated by matrix metalloproteinases (MMPs). We examined the expression of matrix metalloproteinase 9 to support this hypothesis. Materials and methods: The study population consisted of 71 patients with OLP and 10 control patients with oral fibromas. Indirect immunohistochemistry was used for detection of MMP 9 expression (polyclonal rabbit anti‑human MMP antibody). Results: In all cases of OLP, the MMP‑9 expression was seen mainly in the area of lymphocytic inflammatory infiltrate in the lamina propria including lymphocytes within the overlying epithelium. In addition, it was observed in the epithelial keratinocytes, particularly in the stratum basale and stratum spinosum with occasional positivity in the superficial layer. Fibroblasts and endothelium of small vessels in the lamina propria showed MMP9 expression as well. In all cases of oral mucosal fibromas, the MMP‑9 expression was seen only in fibroblasts and in endothelium of small vessels with occasional positivity within the overlying epithelium. It remains unclear, whether MMP‑9 is directly connected to OLP pathogenesis., Vladimíra Paulusová, Jan Laco, Ivo Dřízhal, Radovan Slezák, and Literatura 24

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2012