The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice

Title:

The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice
The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice

Creator:

Kassa, Jiří, Žďárová, Jana, Pavlíková, Růžena, Caisberger, Filip, and Bajgar, Jiří

Contributor:

Kassa, Jiří , 1956-, Žďárová, Jana , 1982-, Pavlíková, Růžena, Caisberger, Filip, and Bajgar, Jiří , 1944-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12017014-e30f13a3-2637-4dc5-965c-5f4d6c087bc5
uuid:bmc12017014-e30f13a3-2637-4dc5-965c-5f4d6c087bc5
local:bmc12017014
http://www.lfhk.cuni.cz/Data/files/Casopisy/2012/2012_27.pdf
local: bmc12017014

Subject:

zvířata, antidota--terapeutické užití, cholinesterasové reaktivátory--terapeutické užití, myši, myši - inbrední kmeny, organofosforové sloučeniny--toxicita, oximy--terapeutické užití, pyridinové sloučeniny--terapeutické užití, krysy, potkani Wistar, and trimedoxim--terapeutické užití

Type:

model:article, article, Text, statistics, práce podpořená grantem, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin‑inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain. Moreover, both combinations of oximes were found to be slightly more efficacious in the reduction of acute lethal toxic effects in cyclosarin‑poisoned mice than the antidotal treatment involving single oxime. Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings a beneficial effect for its ability to counteract the acute poisoning with cyclosarin., Jiří Kassa, Jana Zdarová Karasová, Růžena Pavlíková, Filip Caisberger, Jiří Bajgar, and Literatura 36

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2012